Patients With Ulcerative Colitis Who Achieve Mucosal Healing Protected Against ...

View PDF | Print View
by: Guest Total views: 172 Word Count: 379   

By Ed Susman

SAN ANTONIO, Tex -- October 22, 2010 -- If patients with ulcerative colitis who take infliximab achieve very good mucosal healing within 8 weeks of treatment, they have a 95% chance of avoiding a colectomy over the course of the next year, researchers said here at the American College of Gastroenterology (ACG) 75th Annual Scientific Meeting.

Among the 120 patients who achieved mucosal healing (Mayo Clinic endoscopic subscore classification of 0) after 8 weeks of therapy, only 6 individuals went on to require a colectomy procedure, said William Sandborn, MD, Mayo Clinic, Rochester, Minnesota.

Of the 175 patients in the study who achieved as score of 1, 8 of these patients required colectomy within the next year, which translates to a 95% chance of avoiding colectomy, said Dr. Sandborn on October 19.

Of the 114 patients who had a score of 2 after 8 weeks of therapy, 14 required a colectomy, translating to an 87% chance of avoiding colectomy.

Of the 57 patients who had a score of 3 after 8 weeks of initial therapy, 10 went on to have a colectomy, which translates to an 80% chance of avoiding surgery.

When patients who achieved Mayo scores of 0 or 1 were compared with patients whose endoscopic scores were 2 or 3, the patients with lower scores were more likely to avoid colectomy at 1 year ( P

"There is a tendency to treat patients until their symptoms of ulcerative colitis -- abdominal pain and rectal bleeding and the need for corticosteroids -- are relieved," Dr. Sandborn said. "This study adds evidence that mucosal healing as observed through endoscopy can predict if that person will require surgery down the road."

Dr. Sandborn and colleagues pooled results of 2 clinical trials in which treatment with infliximab was compared with patients who were treated with placebo. The researchers found that infliximab patients who achieved lower endoscopy scores at week 8 were also more likely to achieve symptomatic remission at week 30. About 71% of those patients who had a score of 0 after 8 weeks were symptom free at week 30 compared with 10% of those patients with a score of 3 ( P

Additional information:

Phosphatidylcholine for Steroid -Refractory Chronic Ulcerative
Ingentaconnect Treatment of steroid -naive ulcerative colitis
Steroids superior to Remicade for treating Ulcerative Colitis
Treatment in a patient with ulcerative colitis Multifocal
Are there any alternative treatments for lymphatic colitis besides
Effective Maintenance Leukocytapheresis for Patients with Steroid
Steroid Acne with my Colitis Please Ulcerative Colitis Stories
Steroid -refractory Severe Attack of Ulcerative Colitis Clinical
http://www.docguide.com/news/c...

Related "Colitis":

• Inflammatory Bowel Disease Associated With Bone Loss, Vitamin D Deficiency
  D deficient have a significantly increased risk f ...
• Crohn's & Colitis Foundation & David Garrard Host "CCFA Sunday" with the ...
  Colitis Foundation & David Garrard Host "CCFA Sun ...
• ViroPharma Incorporated Reports Second Quarter 2010 Financial Results
  ViroPharma Incorporated reported today its financ ...
• Tremelimumab monotherapy ineffective for advanced colorectal cancer
  NEW YORK (Reuters Health) - Monotherapy with tre ...
• Lisa's road to Ironman: Part 4
  Dr. David Wikenheiser, Naturopathic Physician an ...

Comments

Add Comment